White Matter Degeneration in Huntington’s Disease: A Study of Brain Structure and Cognition

s for Poster Presentations Chapter 8 Association between Brain Volume and White Matter Microstructure in Healthy Controls and HD Gene-Carriers Crawford, H. E., Gregory. S., Hobbs, N.Z., Johnson, H., Cole, J. H., Rees, E. M., Malone, I. B., Sprengelmeyer, R., Durr, A., Leavitt, B. R., Roos, R. A. C., Langbehn, D. R., Landwehrmeyer, G. B., Tabrizi, S., J., & Scahill, R. I. (2014). Association between brain volume and white matter microstructure in healthy controls. Journal of Neurology Neurosurgery & Psychiatry 85(Suppl 1):A39-A40. This abstract was accepted for a poster presentation at the European Huntington’s Disease Network plenary meeting in Barcelona in 2014. I led on the study concept and design, with guidance from Rachael Scahill, Sarah Gregory and Nicola Hobbs. I analysed the data with support from Sarah Gregory. I had help from Rachael Scahill, Sarah Gregory and Nicola Hobbs with drafting of the abstract and creation of the poster. Comments on the final abstract came from all authors. Chapter 10 Interhemispheric Information Transfer Degeneration in Premanifest HD Crawford, H. E., Cassidy, A. M., Tabrizi, S. J., Scahill, R. I., & the TrackOn-HD Investigators. (2016). Association between abnormal interhemispheric information transfer and corpus callosal structure in premanifest Huntington’s disease. This abstract has been submitted and accepted for poster presentation at the Society for Neuroscience conference ‘Neuroscience 2016’ in San Diego, November 2016. I led on 266 the study concept and design, with guidance from Rachael Scahill and Marina Papoutsi. I gained ethical approval, recruited all study participants and collected data for the cognitive task component of the study. I also analysed the imaging data that had been collected previously. Statistical analysis was conducted with generous and patient supervision from Amy Cassidy. Comments on the final abstract came from all authors.